By W. Lochner (auth.), Professor Dr. Wilhelm Lochner, Wolfgang Braasch, Günther Kroneberg (eds.)
The First Adalat Symposium held in Tokyo in 1973, offered vital experimental and scientific effects which have been amassed in Europe and Japan with the hot coronary healing agent. the ecu scientists had a chance to debate the issues and effects in my view with their jap colleagues. the second one Adalat Symposium was once held in Amsterdam inside of a 12 months with the aim of bringing jointly almost always scientists inside of Europe. the consequences mentioned in Tokyo were prolonged and supplemented via extra studies. Contributions in simple technology are offered, yet most vital are these scientific reports, which aid and expand evidence of the drug's efficacy in people. The editors desire to convey their appreciation to all these chargeable for contributing to this record and, specifically, to Dr. M. SPENGLER, Dr. F. EBNER and Dr. okay. BRANDAU for his or her editorial aid, and to Dr. W. BOTTGER for the instruction of the topic Index. we are hoping that this booklet can be a important contribution towards conveying details to physicians and scientists. DiisseldorfjWuppertal, Autumn 1975 W. LOCHNER' W BRAASCH' G. KRONEBERG Contents advent: W. LOCHNER current foundation of Coronary remedy: W. LOCHNER. With eleven Figures 2 consultation I. Chemistry and Experimental Pharmacology (Chairmen: A. FLECKENSTEIN and ok. LANDMARK) Pharmacology of Nifedipine: G. KRONEBERG. With eight Figures 12 dialogue feedback 19 The Chemistry of Nifedipine: F. BOSSERT. With nine Figures 20 Pharmacokinetics of Adalat in Animal Experiments: ok. PATZSCHKE, B.
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Unpublished results (1974). Discussion Remarks KERN: You mentioned in the last part of your paper that the metabolite had no pharmacologic action. Would this mean that there is perhaps a possibility of going to the molecular action of these compounds? For example, to the molecular action on the membrane of the heart muscle cells? There must be a stereochemical arrangement for receptor and drug reaction on this calcium level. SCHLOSSMANN: We have found that the dihydropyridine structure is typical for the effect of this compound and we have found no effects with pyridine compounds.
Because the residues RCR4 may be widely varied, the HANTZSCH synthesis allows the preparation of a very large number of different l,4-dihydropyridines. Of the 2000 derivatives synthesized to date, a great number have been more closely investigated. Of special interest was the 2-nitrophenyl derivative BAY a l04O-nifedipine  (Fig. 7). It must be emphasized that the nitro group attached to the phenyl ring in this compound is in no way to be compared with the nitrates used in the treatment of angina pectoris, which are relatively labile esters of nitrous acid and are often falsely referred to as nitro compounds.
Rotor 40/3; 40000 U/min = 142000 g; temp. 20° C; 15 h). The concentrations of unbound nifedipine were estimated fluorometrically  or by liquid scintillation counting 4 C-nifedipine). e Results and Discussion Studies on the metabolism of nifedipine were performed by evaluating the concentrations of the unchanged substance and its metabolites occurring in the rat plasma and in the urine of rats and dogs. High-voltage electrophoresis of the original urine or of organic solvent extracts of the urine showed that, whatever the dose, the main renal metabolite eliminated is an acid.