Download Allergic Contact Dermatitis: The Molecular Basis by Jean-Pierre Lepoittevin, David A. Basketter, An Goossens, PDF

By Jean-Pierre Lepoittevin, David A. Basketter, An Goossens, Ann-Therese Karlberg, R.J.G. Rycroft

Allergic touch Dermatitis provides all up to date chemical and physio-chemical options for the research and figuring out of allergic touch dermatitis (ACD). The publication covers all points of ACD - dermis penetration and metabolism, id of sensitizers and hapten-protein interplay, together with new options of accelerating significance reminiscent of molecular reputation and quantitative structure-activity relationships. additionally, accomplished references are supplied, making this the main entire on hand text-book for dermatologists.
Allergic touch Dermatitis reaches an equilibrium among primary thoughts and medical purposes and hence provides an important guide to dermatologists, allergologists, biochemists and toxicologists.

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Extra resources for Allergic Contact Dermatitis: The Molecular Basis

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3 Identification Several methods can be employed to identify a compound or material suspected of causing allergic contact dermatitis. A complete elucidation of the structure of the offending agent may not always be necessary. Rough spot tests or screening tests giving information as to the type of compound or compound class may in some cases be sufficient. In most cases, however, it is desirable to elucidate the complete structure of an unknown component with allergenic properties. A combination of several methods is then necessary.

In reversed-phase HPLC, where the silica has been derivatized with a more or less lipophilic carbon chain, the mobile phase is more polar. It is often a mixture of water and an organic solvent such as acetonitrile or methanol. HPLC analyses can be performed on an analytical or a preparative scale. The analytical scale is used for quantitation or for qualitative analysis, where the presence of a certain compound has to be shown. In preparative HPLC, larger amounts of a sample can be injected into the system and fractions containing eluting components can be collected for further analysis or for biological testing.

12). The UV absorption of dehydroabietic acid differs from that of abietic acid. Abietic acid shows high absorption at 242 nm whereas dehydroabietic acid shows almost no absorption at this wavelength. At 267 nm dehydroabietic acid can be detected, but not abietic acid. 7-Oxodehydroabietic acid shows strong absorption at both wavelengths. Thus, determination at both wavelengths should be performed, since analysis at only one of the wavelengths will give misleading results (Fig. 9). In GC, with a flame ionization detector, or in HPLC with UV detection, the intensity of a peak is proportional to the amount of the component detected in a wide concentration range.

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