By P. Lechat, S. Thesleff and W. C. Bowman (Eds.)
Offers a close assessment of present examine into the organic results of aminopyridines and equally appearing components. It makes a speciality of their results on ion channels, and at the ameliorations of contractility that they produce. The features lined diversity from biophysical experiences of easy mechanisms of motion to the particular and capability medical makes use of in human sufferers
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Additional resources for Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses. Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27–29, 1981
21 s to a f i n a l v a l u e of 0 . 5 7 . 8-s p u l s e . g. 02 (n = 15) for V = 120 m V . 02 (n = 2 3 ) . T o o b t a i n r ( 0 ) a p u l s e w a s a p p l i e d a f t e r 6 m i n at r e s t and r(t) d u r i n g the p u l s e w a s e x t r a p o l a t e d to t = 0 o n the a s s u m p t i o n t h a t 4-AP did n o t a f f e c t t h e g a t i n g p a r a m e t e r " n " of the c h a n n e l s n o t b l o c k e d . T h i s n o t i o n w a s c o n f i r m e d in n e a r l y a l l f i b r e s of a r e c e n t t e s t e m p l o y i n g a s i g n a l a v e r a g e r at a n e x p a n d e d t i m e s c a l e .
In squid axons, incidentally, 4-AP acts from either side (Me ves and Pichón, 1977; Yeh and others, 1976 a, 1976 b ) ; so does 3,4DAP which, however, is clearly more effective on internal application (Kirsch and Narahashi, 1978). It is not clear whether this finding is related to the extremely slow onset of 3,4-DAP action in nodes of Ran vier. In either preparation the reversibility of 3,4-DAP effects is poor (squid) to nonexistent (frog). 4-AP action in other nerve preparations such as the axons of Myxicola (Schauf and others, 1976) and the cockroach, Periplaneta americana, (Pelhate and Pichón, 1974; Pelhate and others, 1974, 1975) is compa rable to that in frog fibres.
I f , for a g i v e n d r u g concen t r a t i o n , b l o c k s o l e l y d e p e n d s o n m e m b r a n e p o t e n t i a l , r(«>) s h o u l d b e i n d e p e n d e n t of the v a l u e w i t h w h i c h r s t a r t s a t t h e b e g i n n i n g of a 36 W. -Η. Wagner and J. Schmidtmayer p u l s e . T h i s w a s indeed found b u t a t t a i n i n g e q u i l i b r i u m took c o n s i d e r ably longer than e x p e c t e d from τ ^ , d u e to the a p p e a r a n c e of s l o w e r p h a s e s of e q u i l i b r a t i o n .