By Togas Tulandi, Morrie Gelfand
The topic of androgen remedy in reproductive elderly men and women is attracting expanding curiosity from experts in copy drugs, endocrinology and first care companies, in addition to from sufferers and the media.
The first booklet to hide androgen alternative in males and ladies, Androgens and Reproductive Aging addresses the emotive issues of reproductive getting older, the menopause and using androgen supplementations to mitigate their results.
Edited through top gurus in reproductive drugs and infertility, and boasting an all-star forged of authors, this complete textual content covers:
* androgen creation within the fit female and male
* the decline of androgen construction in the course of getting older, with the linked results on physique composition and libido
* the advantages and strength side-effects of androgen substitute therapy.
Ideal for a variety of clinicians and scientists attracted to reproductive getting older, the menopause, hormone substitute and androgen remedy, in addition to obstetricians, gynecologists and kin practitioners, this distinct textual content is a hugely very important addition to literature within the area.
Read Online or Download Androgens and Reproductive Aging PDF
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Additional resources for Androgens and Reproductive Aging
Abraham GE. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin Endocrinol Metab 1974; 39:340–346. 22. Judd HL, Yen SS, Serum androstenedione and testosterone levels during the menstrual cycle. J Clin Endocrinol Metab 1973; 36:475–481. 23. Sinha-Hikim I, Arver S, Beall G et al. The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 1998; 83:1312–1318.
The effects of androgens on the brain are mediated through androgen receptors as well as by the aromatization of testosterone to estrogen. The cortical and pituitary actions of androgens are mediated through the AR. ARs have been identified in the cortex, pituitary, hypothalamus, preoptic region, thalamus, amygdala, and brain stem. Hypothalamic and limbic system aromatization leads to estrogen receptor-mediated actions. 43 The relation between mood and symptoms of menopause including depression, mood swings, irritability, lethargy, difficulty concentration, insomnia, anxiety and loss of sexual function has been studied extensively.
J Clin Endocrinol Metab1995; 80:3537–3545. Jiroutek MR, Chen MH, Johnston CC, et al. Changes in reproductive hormones and sex hormone-binding globulin in a group of postmenopausal women measured over 10 years. Menopause 1998; 5:90–94. Laughlin GA, Barrett-Connor E, Silverstein D, et al. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000; 85:645–651. Longcope C, Franz C, Morello C et al. Steroid and gonadotropin levels in women during the perimenopausal years.