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By Paul & Christopher Shores Camelio

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Source: Figure 1 of (Rothman, 1976). 29 Alfredo Morabia The same risk factor can be strong in one population if its complement causes are common, and weak in another if its complement causes are rare. The textbook by Rothman and Sander Greenland, epidemiologist at University of California, Los Angeles (Rothman and Greenland, 1998, pp. 9-11) provides a numerical example, which is very useful for illustrating these concepts. 7. Evolution of population thinking in epidemiology Let us at this point synthesize the lessons of the examples reviewed above.

23). The data reported by Louis can be revisited with modern analytical tools (Morabia, 1996). htm. We can compare the prevalence of early bleeding in the group of patients who died with those who survived. Or we can compare the death risk in those bled in the first four days after disease onset vs. those bled more than four days after disease onset. 07). Also, if patients bled later in the course of the disease had a better prognosis, because they had already passed the worst phase of the illness, the bias would have favored late bleeding.

Gums hemorrhaged and their tissue became weak and spongy. Teeth loosened and eating became difficult and painful. Stupor and death followed rapidly. 33 Alfredo Morabia Table 9- Description of treatment and outcomes in James Lind's 1747 experiment on 6 pairs of seamen suffering from scurvy. Source: (Lind, 1753). Experimental pairs Treatment for each pair member Qualitative outcome 1 "a quart of cider a day" "twenty five gouts of elixir vitriol three times a-day, upon an empty stomach, using a gargle strongly acidulated with it for their mouths" "two spoonfuls of vinegar three times a-day upon an empty stomach, having their gruels and their other food well acidulated with it, as also the gargle for their mouth" "improved" "mouth but not internal improvement" "half a pint of sea water every day, and sometimes more or less as it operated, by way of gentle physic" "no remarkable alteration (.

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