By Piero Picci MD (auth.), Piero Picci, Marco Manfrini, Nicola Fabbri, Marco Gambarotti, Daniel Vanel (eds.)
This ebook displays the event of the Rizzoli Orthopedic Institute in the course of greater than a hundred years of therapy of musculoskeletal tumor and tumorlike lesions. It offers a variety of lesions from a multidisciplinary point of view, highlighting pertinent medical, radiological, and histological correlations. therapy is in short stated for every entity. furthermore, the newer biomolecular findings of use for analysis, diagnosis, and therapy are conscientiously analyzed. The Rizzoli case archive spans greater than a century, the 1st handled case courting again to twenty-eight September 1900, and includes the unique fabric – medical charts, imaging, paraffin blocks, and histological slides – of greater than 40,000 instances, together with approximately 29,000 bone lesions and 11,000 smooth tissue lesions. This publication stories the main suitable entities and displays the advancements in wisdom of musculoskeletal tumors as offered throughout the every year overseas direction held on the Rizzoli Institute.
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Extra info for Atlas of Musculoskeletal Tumors and Tumorlike Lesions: The Rizzoli Case Archive
In low-grade chondroid lesions, the site of the lesion is very important for a correct interpretation of histology: if the lesion is in the small bones of the hands and feet, it is usually benign, while, with the same histological features, it is usually malignant if located in the ribs and sternum. Lesions that arise in the periosteum are generally clinically less aggressive than the medullary counterparts. The radiographic features of the lesion as well are very important for the pathologist: they have to be considered like a negative image of the macroscopic appearance of the neoplasm.
Review Dujardin F, Binh MB, Bouvier C, Gomez-Brouchet A, Larousserie F, Muret AD, Louis-Brennetot C, Aurias A, Coindre JM, Guillou L, Pedeutour F, Duval H, Collin C, de Pinieux G (2011) MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. Mod Pathol 24:624–637 Dumitrescu CE, Collins MT (2008) McCune-Albright syndrome. Orphanet J Rare Dis 3:12 Ruggieri P, Sim FH, Bond JR, Unni KK (1994) Malignancies in fibrous dysplasia.
2) Great number of slightly plump and well-stained nuclei; rare and normal mitotic figures (active areas of the lesion). (3) Small and sparse giant cells, less numerous cells and more abundant collagenous bundles (florid stage). (4) Foam cells (regressive phenomena of the tumor) Selected Bibliography Betsy M, Kupersmith LM, Springfield DS (2004) Metaphyseal fibrous defects. J Am Acad Orthop Surg 12:89–95 Jee WH, Choe BY, Kang HS et al (1998) Nonossifying fibroma: characteristics at MR imaging with pathologic correlation.