By Paul G. Walfish
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Extra resources for Autoimmunity and the Thyroid
A few allotypes are mutually exclusive on a particular haplotype. To facilitate identification, allotypes were originally designated in alphameric code, but more recently have been classified according to the WHO coding using a numerical system. The Immunogenetic Basis of Autoimmune Thyroid Disease 15 On the basis of population and family studies, it has been demonstrated that gamma and alpha 2 allotypes are inherited in specific combinations (or haplotypes) , whereas kappa chain markers segregate separately, resulting in certain allotype combinations being unexpectedly frequent, while others do not occur· Serum levels of IgG subclasses appear to be influenced by Gm allotypes with IgG3 levels being twice as high in G3m(5) homozygotes, as in G3m(21) homozygotes, while hétérozygotes have intermediate to high levels of IgG3· Also, the biological properties of Ig subclasses differ with the allotypic determinants present, thereby influencing the efficiency of phagocytosis (Schanfield, 1980).
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