By Harald Schütz
" ... this can be a superb compilation of information which may be at the bookshelves of all analysts attracted to the benzodiazepines. it truly is to be was hoping that, with the creation of such a lot of new ben zodiazepines, the writer will quick upload those in a moment edi tion" (A. C. Moffat in: developments in Analytical Chemistry, 1983). This assessment, deputizing for plenty of others, displays the pleasant reception loved through the 1st quantity of Benzodiazepines, which was once released in 1982 and it seems that closed a niche within the ben zodiazepine literature. meanwhile, Benzodiazepines has demonstrated itself as a typical e-book, as evidenced via a number of letters and quotations. feedback have been additionally quickly made for a brand new version in view of the surprisingly swift improvement within the box of the benzodiazepines. It grew to become quick noticeable, besides the fact that, that it should now not be adequate to put up a revised moment version, yet thoroughly new moment quantity will be required for which, although, the profitable past structure should be mostly retained. the subsequent concerns look worthy stating in reference to the guidance of quantity II: - to make sure continuity with quantity I so far as attainable, the record of references was once consecutively numbered (references 1 to 3779 in quantity I, references 3780 to 11338 in quantity II). while in Vol. I the components seem within the sequential order in their historic improvement they're indexed in alphabetical order in Vol. II.
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Additional info for Benzodiazepines II: A Handbook. Basic Data, Analytical Methods, Pharmacokinetics, and Comprehensive Literature
NFN) K 373 W4020 Centrac - Centrax - Demetrin R - Lysanxia - Mono-Demetrin R - Prazene - Reapam - Trepidan - 21 Quazepam (Vol. II, subst. L) Sch 16134 Oniria - Quazium - Temazepam (Vol. I. subst. L; NFN) ER 115 K 3917 Wy 3917 Cerepax - Euhypnos - Levanxene - Levanxol - Mabertin - Normison - Planum R - Remestan R - Restoril Signopam - Somaz - Texapam - Tonirem - Tetrazepam (Vol. I, subst. L, NFN) CB 4261 Musaril R - Myolastan - Tofisopam (Vol. II, subst. L, NFN) Egyt 341 Serie! - Tavor - Triazolam (Vol.
O OMACB 8 I- 10 :l: u.. u o OCCB ADB o ~ ACFB MNFB 10 o o o o ACB ANFB +ANCB ANB Start QABP _ _ _ _ _ _ _ _ _ _ _ _ Fig. 2. Positions of the acid hydrolysis products (aminobenzophenones) of some newer benzodiazepines (solvent: toluene; sorbent: silica gel 60 F••• ; see  and  for more details). Abbreviations: ABFB 2-amino-5-bromo-2'-fluorobenzophenone (from haloxazolam); ACFB 2-amino-Schloro-2'-fluorobenzophenone (from ethyl loflazepate, N-desalkyl-2-oxoquazepam, N-desmethyl-fludiazepam, and other metabolites); ADB 2-amino-2' ,5dichlorobenzophenone (from cloxazolam, delorazepam, mexazolam, and lorazepam); CFTB 5-chloro-2'-fluoro2-(2,2,2-trifluoroethyl-amino)benzophenone (from quazepam, 2-oxoquazepam and 3-hydroxy-2-oxoquazepam); CPB S-chloro-2-(2-propinyl)benzophenone (from pinazepam and 3-hydroxy-pinazepam); CFMB 5-chloro2'-fluoro-2-methylaminobenzophenone (from fludiazepam and 3-hydroxy-fludiazepam); MNB 2-methylamino5-nitrobenzophenone (from nimetazepam).
2 \ ''\ \ \ ''\, \ \ '\, -"-' "....... 1 rno 1/ 1 ) ---- NaOH ( O. 4 \\. , ...... 2 " "- '" .....