By Mahmoud A. Saleh, Jerry N. Blancato, Charles H. Nauman
content material: Biomonitoring for pesticide publicity / C.H. Nauman, John A. Santolucito, and Curtis C. Dary --
Modeling cytochrome P-450 mediated acute nitrile toxicity utilizing theoretical linear solvation strength relationships / George R. Famini, Leland Y. Wilson, and Stephen C. DeVito --
adjustments in biochemical and molecular organic parameters triggered by way of publicity to dioxin-type chemical substances / Alan Blankenship and Fumio Matsumura --
legislation of muscarine receptors as biomarkers of publicity to pesticides / Amira T. Eldefrawi, David A. Jett, and John C. Fernando --
Correlations of molecular connectivity indices with toxicities of natural nitriles / Gordon G. money --
Computer-aided molecular modeling for improvement of biomarkers for human publicity to insecticides / Mahmoud A. Saleh, Cecil Wallace, Jr., and Jerry N. Blancato --
A biosensor for tracking blood cholinesterases as a biomarker of publicity to organophosphorus anticholinesterase insecticides / Mohyee E. Eldefrawi, Kim R. Rogers, Nabil A. Anis, Roy Thompson, and J.J. Valdes --
Hair as a aim tissue for constructing a organic marker for precursors to 2,5-hexanedione / Deadre J. Johnson, Leon Lack, and Mohamed B. Abou-Donia --
Hemoglobin adducts of insecticides / Frank C. Schnell --
Immunoassay for p-nitrophenol in urine / Kim R. Rogers and J.M. Van Emon --
Isolation of pesticide-binding protein from rat blood / G.L. Larsen, K.L. Davison, J.E. Bakke, and N.M. Bass --
physique burden and nonoccupational publicity overview / John A. Santolucito --
persistent organophosphorus publicity : biomarkers within the detection of immune disorder and the advance of lymphomas / David S. Newcombe, Ali M. Saboori, and Ahmed H. Esa --
Validation of a pharmacokinetic version to foretell publicity of flooring growth mixer-loader-applicators to chlorophenoxyacetic acid herbicides : comparability to traditional techniques / D.G. Baugher --
Dermal absorption and disposition of formulations of malathion in Sprague-Dawley rats and people / Curtis C. Dary, Jerry N. Blancato, Mark Castles, Vijayapal Reddy, Michael Cannon, Mahmoud A. Saleh, and Gordon G. funds --
Physiologically established pharmacokinetic versions : examples in their use in publicity and probability evaluation / Jerry N. Blancato and Mahmoud A. Saleh --
Prediction of anticholinesterase job and urinary metabolites of isofenphos : use of a percutaneous physiologically dependent pharmacokinetic-physiologically dependent pharmacodynamic version / J.B. Knaak, M.A. Al-Bayati, O.G. Raabe, and Jerry N. Blancato --
Analytic answer of a linear physiologically dependent pharmacokinetic version prototype important in threat evaluation / Robert N. Brown.
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Extra resources for Biomarkers of Human Exposure to Pesticides
We understand that cytochrome P4501A1 induction, for instance, is a very sensitive and specific method to monitor relative effects of these chemicals. However, we also know that it has a number of drawbacks, the most important one being that it is an unsuitable indicator of the lethal effect of dioxin-type chemicals among various animal species. Furthermore, these chemicals are known to cause a variety of symptoms in different tissues and, therefore, we do need additional bioassay methods on sensitive types of cells expressing specific lesions that are unrelated to cytochrome P450s.
Biochem. Physiol. 1972, 2, pp 95-112. P. Toxicol Appl. Pharmacol. 1981, 59, pp 589-602. ; Hassan, M. Drug Metab. Disp. 1982, 10, pp 495-498. H. Toxicol. Lett. 1982, 12, pp 157163. ; Hashimoto, K. Arch. Toxicol. 1984, 55, pp 47-54. ; Hashimoto, K. Toxicol. Lett. 1984, 22, pp 267-272. ; Hashimoto, K. Arch. Toxicol. 1985, 57, pp 88-93. J. Fundam. Appl. Toxicol. 1986, 7, pp 690-697. (13) Yoshikawa, H. Med. Biol. 1968, 77, pp 1-4. H. ; Academic Press: London, 1981; pp 51-60. V. J. Toxicol. Environ. Health 1985, 16, pp 449-460.
115 T L S E R descriptors Ttj t q. 057 log(l/LD,5o &) exp calcd resid ' . Logarithm of the octanol/water partition coefficient; obtained from ref 18. Molecular volume. Polarizability index, d Molecular orbital acidity. Electrostatic basicity, f Theoretical reaction rate constants statistically corrected for metabolism at other positions; obtained from ref 18. g Acute median oral lethal dose i n mice, mmol/kg. Λ Calculated using equation 6. ' Residual; exp minus calcd log(l/LD5o) values. 7 Obtained from ref 9.