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Additional info for Bladder Cancer - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Craig Nichols and Richard Foster (Testicular Cancer Subcommittee: Co-chairs), Dr. Bruce Roth (Prostate Cancer Subcommittee: Cochair), and Drs. Scott Saxman and Anne Greist (Toxicity Monitoring Committee). Susan Fox has served as the GU Nursing co-chair from 1995-1997 and was nice chair and chair of the Nursing Committee for 1997. Major contributions of IUMC have been that of scientific leadership of innovative trials. Several ECOG trials designed by IUMC investigators have been presented at the American Society of Clinical Oncology meetings including the Plenary session.
Imbalance between apoptosis and proliferation also is a risk factor of bladder cancer. Aim 3 will determine whether ITCs or NAC-ITCs can correct the imbalance between apoptosis and proliferation associated with bladder carcinogenesis: Do ITCs or NAC-ITCs induce apoptosis and/or inhibit cell cycle progression in bladder cancer cells? If so, what is the underlying mechanism(s)? Aim 4 will evaluate in rivo the effect of orally administered ITCs on important biomarkers, including the Phase 2 enzymes described in Aim 1, apoptosis (TUNEL), and proliferation (PCNA) in the bladder epithelium of F344 rats.
The core preliminary data for this proposal is provided by our genome-wide model of urinary bladder cancer progression from occult in situ preneoplastic conditions to invasive cancer. The data was generated by a strategy of whole organ histologic and genetic mapping developed in our laboratory. e its progression from preneoplastic conditions to invasive cancer. Our model provides data on over 30 putative tumor supressor gene loci involved in the development and progression of urinary bladder cancer.