Download Bone Metastases from Prostate Cancer : Biology, Diagnosis by Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, PDF

By Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, Riccardo Valdagni

This booklet provides updated details on one of many most well liked issues in prostate melanoma, specifically bone metastases. the latest advancements with admire to biology, pathology, prognosis, and therapy are defined, offering readers with an exceptional figuring out of the mechanisms of metastasis formation, the features of metastases, their aggressiveness, and prognostic elements for therapy reaction. The assurance contains dialogue of the entire top to be had recommendations (laboratory, radiology, and nuclear drugs) for attaining early prognosis and either demonstrated and novel healing techniques. distinct info is supplied on hormonal manipulations, bone-targeted brokers, vaccines, taxanes, and different remedies which are enriching the healing armamentarium. The editors will be thought of leaders within the box, with nice adventure in diagnostic and scientific oncology and examine, and the authors are specialists in diversified specialties. This guarantees a multidisciplinary strategy, mirroring the present state of affairs within which therapy in sufferers with bone metastases is undertaken via a workforce of experts and healthiness pros in numerous fields.

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Extra resources for Bone Metastases from Prostate Cancer : Biology, Diagnosis and Management

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31. 32. 33. 34. 35. 36. 37. over and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: the TUGAMO study. Br J Cancer 109(1):121–30 Brasso K, Christensen IJ, Johansen JS, Teisner B, Garnero P, Price PA, Iversen P (2006) Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate 66(5):503–513 Coleman R, Body JJ, Aapro M et al (2014) Bone health in cancer patients: ESMO Clinical Practice guidelines.

Interestingly, the knockdown of PMEPA1 has been associated with increased prometastatic gene expression and bone homing in PCa mouse models [36]. Furthermore, TGF-β expression resulted increased in BMs compared to visceral PCa metastases in a series of 149 visceral and BMs from 62 patients with castration-resistant PCa [37]. In this study, nuclear Twist, Slug, and Zeb1 localization and an EMT-like phenotype were present only in a small subset of castrationresistant PCa BMs [37]. E-cadherin is involved in maintaining the pluripotent and self-renewal ability of prostate CSCs [28, 38, 39].

39. 40. by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55:5195–5199 Kuo YC, Su CH, Liu CY, Chen TH, Chen CP, Wang HS (2009) Transforming growth factor-β induces CD44 cleavage that promotes migration of MDAMB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase. Int J Cancer 124:2568–2576 Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM (2005) Transcriptional activation of integrin β6 during the epithelial–mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma.

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