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By Herbert F Spirer

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Pharmacokinetics and biotransformation of chlorpropamide in man. Glin. Pharmacol. Ther. 13: 710 (1972). 6. W. H. Barr, L. M. Gerbracht, K. Letcher, M. Plaut, and N. Strahl. Assessment of the biologic availability of tetracycline products in man. Glin. Pharmacol. Ther. 13: 97 (1972). 7. K. C. Yeh and K. C. Kwan. A comparison of numerical integrating algorithms by trapezoid, Lagrange, and spline approximation. J. Pharmacokinet. Biopharm. 6: 79 (1978). 8. T. Walle, T. C. Fagan, E. C. Conradi, U. K.

This lag may be the result of delayed release of drugs from the dosage form or of a combination of negligible absorption from the stomach and slow gastric emptying. One usually concludes the existence of a time lag if the intersection of the extrapolations of the terminal exponential phase and residual line occurs at a time greater Pharmacokinetics 36 than zero. If there is no lag time, both extrapolations intersect the log concentration axis at the same point. When a lag is evident, the appropriate equation to describe the time course of drug concentrations in plasma is -k (t-t ) kaFX -K(t-t ) O a 0 J 0 - e C = V(k _ K) [e (1.

The dashed line denotes the decline of drug concentration in plasma after an infusion period shorter than the time required to reach steady state. total area under the concentration versus time curve. The area under the up-curve is obtained by integrating Bq , (1. 64) from t = 0 to t = T. The area under the down-curve is obtained by integrating Eq. (1. 74) from t' = 0 to t' = 00. Combining these areas and simplifying terms yields kOT (1. 80) AUC = VK Therefore, CI s kOT = VK = - AUC (1. 81) and (1.

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