Download Calcium Signaling In Airway Smooth Muscle Cells by Lin Mei, Yun-Min Zheng, Yong-Xiao Wang (auth.), Yong-Xiao PDF

By Lin Mei, Yun-Min Zheng, Yong-Xiao Wang (auth.), Yong-Xiao Wang (eds.)

This ebook explores the function calcium signaling performs in mobile responses in just about all forms of cells together with airway soft muscle cells. This common signaling can result from extracellular calcium inflow and/or intracellular calcium unlock, that are accurately managed and controlled by way of ion channels, exchangers and/or transporters at the plasmalemmal or sarcoplasmic reticulum membrane. First, a number of chapters aspect calcium unlock channels (ryanodine receptors and inositol trisphosphate receptors), voltage-dependent potassium channels, temporary receptor strength channels, Orai channels, calcium-activated potassium channels, and calcium-activated chloride channels. Well-characterized sodium-calcium exchangers, voltage-dependent calcium channels, and calcium pumps are defined additionally intensive over many chapters.

Ca2+ signaling may be expressed in Ca2+ sparks, waves, oscillations, and worldwide alterations in intracellular Ca2+ focus. Calcium in subcellular cubicles (cytosol, sarcoplasmic reticulum, mitochondria, and caveolae) additionally convey dynamic crosstalk. Many molecules together with FK506 binding proteins, cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA kinases, caveolin and integrins can regulate and result in spatial, temporal and compartmental diversifications of calcium signaling. furthermore, calcium signaling can show intercourse hormone- and age-dependent alterations. a couple of chapters are devoted to overlaying those varied codecs, spatiotemporal features, multifaceted community and mathematical modeling of Ca2+ signaling.

Neurotransmitters, hormones, development elements, inflammatory cytokines, and different stimuli could lead on to a number of mobile responses via inducing Ca2+ signaling in airway delicate muscle cells. expanding facts means that Ca2+ pumps and canonical brief receptor power channels are crucial for airway soft muscle home improvement. consequently, a number of chapters summarize contemporary advances within the reviews of the main position of calcium signaling in physiological mobile responses in addition to the improvement of bronchial asthma, persistent obstructive pulmonary sickness and different respiration problems.

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Extra info for Calcium Signaling In Airway Smooth Muscle Cells

Example text

3 Kv7 Potassium Channels in Airway Smooth Muscle Cells . . . . . . . . . . . . . . . 4 Prospects for Future Developments . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

3 Physiological Functions of TRPs, Orais, and Stims . . . . . . . . . . . . . . . . . . . . 1 Controlling the Resting Membrane Potential and [Ca2+]i in ASMCs . . . . . . . . 2 Regulation of [Ca2+]i in ASMCs . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Functional Roles of TRPs, Orais, and Stims in Respiratory Diseases . . . . . . . . . . . 1 Asthma .

L. Byron et al. , other smooth muscles, skeletal muscle, neurons, epithelia)? Identifying drugs that selectively activate Kv7 channels in ASMCs might facilitate development of bronchodilators with relatively few off-target actions. Can aerosolized formulations of Kv7 channel activators be used to relax hyperconstricted airways and minimize off-target effects? , β2-adrenergic receptor agonists, corticosteroids) in the treatment of asthma or other airway diseases? 5 Summary In summary, the recent discovery that Kv7 potassium channels are expressed and functional in ASMCs, and that altering their activity can influence airway diameter, suggests that these channels may play an important role in airway physiology.

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