Download EBNA1 and Epstein-Barr Virus Associated Tumours by Lori Frappier PDF

By Lori Frappier

This SpringerBrief is entire account of the services and results of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and facts for EBNA1 contributions to those cancers. EBNA1 used to be the 1st EBV protein detected and the main serious for EBV latent an infection. EBNA1 fulfills a number of services at EBV genomes that have been defined in lots of (sometimes complicated) studies over the past 28 years. whereas those have been at the beginning regarded as the single roles of EBNA1, many experiences lately have proven that EBNA1 additionally at once impacts mobile techniques in ways in which will be anticipated to give a contribution to oncogenesis. although, the measure to which EBNA1 promotes phone survival and oncogenesis in a number of varieties of human tumours isn't totally transparent and a question of discussion. This booklet deals a present synopsis of EBNA1 capabilities in EBV latency, together with features in DNA replication, mitotic segregation and transcription. Mechanisms of those EBNA1 features can also be mentioned in addition to implications for tumourigenesis. moreover, the mobile results of EBNA1 may be reviewed, together with how EBNA1 manipulates particular mobile proteins and relationships to EBV-associated lymphomas and carcinomas.

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Requirements for EBNA1-induced permanganate sensitivity of the Epstein-Barr virus latent origin of DNA replication. Journal of Biological Chemistry, 272, 26434–26440. Wood, V. , O’Neil, J. , Stewart, S. , Dawson, C. , & Young, L. S. (2007). Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFbeta signaling pathways. Oncogene, 26, 4135–4147. , & Frappier, L. (2002). Separation of the DNA replication, segregation and transcriptional activation functions of Epstein-Barr nuclear antigen 1.

DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: Stabilization of an origin complex with Epstein-Barr nuclear antigen 1. Proceedings of the National Academy of Sciences USA, 88, 10870–10874. , Barwell, J. , Pfuetzner, R. , Edwards, A. , & Frappier, L. (1996). Cooperative assembly of EBNA1 on the Epstein-Barr virus latent origin of replication. Journal of Virology, 70, 1228–1231. , & Frappier, L. (1997). Requirements for EBNA1-induced permanganate sensitivity of the Epstein-Barr virus latent origin of DNA replication.

Et al. (2011). Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicellazoster virus. PLoS Pathogens, 7, e1001266. , Ferguson, B. , Wyllie, A. , & Rich, T. (2008). New insights into the role of PML in tumour suppression. Cell Research, 18, 622–640. , Holowaty, M. , et al. (2005). Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Molecular Cell, 18, 25–36. , & Frappier, L.

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