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By Kenneth B. Cummings

content material: Anatomic Radical Prostatectomy. Conformal Radiation remedy. Brachytherapy: sufferer choice and medical consequence. Brachytherapy through Conformal 3D exterior Beam treatment. PSA development after Radical Prostatectomy: function for Radiation treatment. Timing of Hormone Deprivation for PSA development Following neighborhood treatment. Novel remedy for PSA development in Absence of Imagable illness Following neighborhood remedy. replacement drugs within the administration of PSA development Following neighborhood treatment. destiny Prospectives: Vaccines and Gene remedy in Prostate Cancer.

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Sample text

We do not advocate bladder neck sparing, as the risk of a positive margin at the bladder neck far outweighs the minimal added time and technical ease of bladder neck reconstruction.  Therefore, treatment outcomes and cancer control should be based primarily on postoperative monitoring of the serum PSA level. Actuarial nonprogression rates in patients undergoing radical retropubic prostatectomy for clinical stage T1 and T2 prostate cancer have been reported by multiple institutions, revealing approximately 80% nonprogression at 5 years and Page 38 TABLE 11 Actuarial 5­Year Progression­Free Probability Rates After Radical Retropubic Prostatectomy, Determined by Prostate­Specific Antigen (PSA), for Clinical Stage T1 and T2 Prostate Cancer.

We further developed a nomogram that displays these associations derived from a Cox proportional hazards model using only preoperative, or a combination of preoperative and intraoperative, parameters [103] (Table 9) TABLE 9 Results of Cox Proportional Hazards Analysis for Prediction of Spontaneous Recovery of Erections for 314 Patients Undergoing Radical Prostatectomy Since 1993 for cT1a­T3a Prostate Cancer Based on Preoperative Parameters and the Combination of Preoperative and Intraoperative Parameters.

80. 0001 Page 43 FIGURE 21 PSA progression­free survival for low­risk (A), intermediate­risk (B), and high­risk. , unpublished data used with permission) not reported in D’Amico et al [134].  While the authors acknowledge that such comparisons have limitations, they conclude that such data provide a better comparison of biochemical progression than previously reported studies and emphasize the need for caution in interpreting the relative efficacy of brachytherapy in controlling localized prostate cancer [135].

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