Download Stereotaxis in Parkinson Syndrome: Clinical-Anatomical by Professor Dr. med. Rolf Hassler, Professor Dr. med. Fritz PDF

By Professor Dr. med. Rolf Hassler, Professor Dr. med. Fritz Mundinger, Professor Dr. med. Traugott Riechert (auth.)

Despite the superb growth made through the stereotactic method, relatively concerning the localization of the objective, regardless of the intense warning, which stereotactic neurosurgeons practice at each step of the approaches, regardless of the regimen roentgenologic and physiologic controls (depth EEG, electrical stimulation) previous the creation of a lesion, there is still a definite measure of uncertainty concerning the place, form and quantity of the lesion in addition to of the electrode song and likewise concerning unintentional lesions within the area. the ultimate resolution to those questions will depend on the anatomical regulate. hence we needs to be thankful to the authors, who played 3700 subcortical stereotactic interventions, that they current a cautious comparability of the scientific and of the pathologic­ anatomic findings, within the situations whose brains should be studied. They reveal what measure of exactness could be anticipated from the stereotactic method. in addition they current a cautious define of the morphology, body structure, biochemistry and pathology of the buildings which are affected in Parkinson sufferers. moreover this monograph allows one to familiarize oneself with the equipment of stimulation and destruction practiced via the authors. The appropriate literature is rigorously quoted. A examine of this mono­ graph will profit not just the stereotactic neurosurgeon, but in addition neurophysiologists, pathologists and working towards neurologists.

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HIIWIlIlIlIIJII! U lIuH, NI~ Ii ! 'II~~III*~~~1I,d1 30' later postnI grot tron sect ion 0. 5 sec ~. ~l. i\\. l'ii\:amroot ~ ~b. filJlt ~ %h~w ll\~ \~ ~:a :s\~~ Y; %~" :a~\'v~m ~V) :a\\\\ \~\U:at :areli~~ ~:a :sm:anret Y; i\.. \lM:::a ~w ilk %~~ ~~V):a~ '3mOO% lhrem. rem\~.. n ~~t~~ tl\~ ~ft. ~ ~~~. ':' 2 Res ~ 5mg/kg stretch ~. md\ . \\~ :sl~ $.. F~n~~ $~;q l~ 11' :areh'Vii~ 4 stretch 5 ..... \... lJ .. ~ 41. Wjq; L~~~ :a :s1l~w :s\. ;.. :s lM :sl~ fut m:a~ ~d% $.. :a\\. reool~. ~ ~ t~~l) 38 Basis of the Parkinson Syndrome: Morphology, Physiology, Biochemistry, and Pathology synapse.

Insert (d) shows Lewy's glassy nerve cell alteration, by which basal nucleus nerve cells deteriorate. The normal senile involution of these nerve cells, as shown in (b) is precocious and enhanced in Paralysis agitans. (After HASSLER, 1938) Substantia Nigra 33 .. ", , - . --" ,'8 ~' • sii . I ,- 0" , -. ", . .. . :. :' . • ' . ~. , .. # ; ~ " .. 1 : . ,. . .... ; ' . :. . '- 34 Basis of the Parkinson Syndrome: Morphology, Physiology, Biochemistry, and Pathology nigra or the substantia nigra itself have been damaged.

The nigra neurons take up specifically catecholamines (without differentiation of NA and DA), and some synapses in the nigra take up indolamines. This pattern of uptake in the nigra makes it very credible that DA is the transmitter formed by nigra neurons. Fig. 13. (a) Light-microscopic autoradiogram of substantia nigra after administration of 3H-dopamine into brain ventricles of rat. An accumulation of silver grains due to radioactive dopamine deposit is seen, also in perikarya of nigra cells, and in long rows (arrow) that correspond to dendrites of nigra nerve cells.

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