By Univ. Professor Dr. Wolfgang P. E. Raab (auth.)
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Extra info for The Treatment of Mycosis with Imidazole Derivatives
Another type of interaction must be considered when the preparation is applied to the outer skin: interactions with substances on the skin surface (proteins, lipids). The main proteins to be considered are keratin and the serum proteins found on the skin surface in severe inflammation. The principal lipids are those secreted by the sebaceous glands. The possible interactions between imidazole derivatives and lipids merit special consideration, for these drugs are capable of reacting with the lipids of cellular and subcellular membranes (see Sect.
The results of the Warburg test demonstrate that econazole nitrate is at least equal to the other dermatologically used broad-spectrum antimicrobials in its antibacterial action, as far as gram-positive organisms are concerned. But since it is the gram-positive bacteria which cause secondary infections in inflamed skin lesions and especially in superficial dermatophytoses (tinea) and candidoses, the activity of the imidazoles against gram-positive bacteria greatly enhances their value in the treatment of mycotic infections (see Sect.
HN0 3. 68. 70. 3 Physical Properties Econazole is a white, odorless, amorphous or microcrystalline powder with a melting point between 160 and 168 C. 1 mol/liter HCl). The stability of econazole is excellent in dissolved and undissolved form in contrast to other antifungal drugs even at room temperature ' Econazole 0 0 19 is nonhygroscopic. 05%). Econazole nitrate shows good solubility in methanol and dimethyl formamide. For purity testing, it is important that the chemical structure of econazole can be verified according to standard procedures by the following methods: ultraviolet absorption, infrared absorption, NMR absorption, and mass-spectrographic analysis.